The Impact of Post-Translational Modifications on Protein Aggregation in Genetic Disorders

Okafor, Azubuike Ikechukwu and Ogar, Boniface Oyigoja

Department of Medical Biochemistry, University of Cross River State, Calabar, Nigeria

Email: okafor.azubuike@gmail.com; phone number: +2348035723454

                                                                          ABSTRACT

Protein aggregation is a hallmark of various genetic disorders, often resulting from abnormal protein folding that leads to the accumulation of insoluble fibrils within cells. Post-translational modifications (PTMs), which occur after protein synthesis, play a crucial role in regulating protein structure, function, and aggregation propensity. This paper explores the intricate relationship between PTMs and protein aggregation in genetic disorders, focusing on how specific modifications contribute to or prevent the formation of protein aggregates. By examining the molecular mechanisms underlying PTM-induced protein aggregation, this review provides insights into potential therapeutic strategies targeting PTMs to mitigate the effects of protein aggregation in diseases such as Alzheimer’s, Parkinson’s, Huntington’s, and other proteinopathies.

Keywords: Protein Aggregation, Genetic Disorders, Post-Translational Modifications (PTMs), Neurodegeneration, Protein Misfolding.

CITATION: Okafor, Azubuike Ikechukwu and Ogar, Boniface Oyigoja (2023). The Impact of Post-Translational Modifications on Protein Aggregation in Genetic Disorders. Research Output Journal of Public Health and Medicine 2(1):1-4.