Nanotechnology in Medicine: Targeted Drug Delivery Systems

Mugo Moses H.

School of Natural and Applied Sciences Kampala International University Uganda

ABSTRACT

Nanotechnology has revolutionized the field of medicine by enabling the precise manipulation of materials at the atomic and molecular levels, leading to the development of highly efficient targeted drug delivery systems. These systems enhance therapeutic efficacy, minimize side effects, and improve patient compliance. This paper explores the fundamentals of nanotechnology, the architecture of drug delivery systems, and the role of nanocarriers both organic and inorganic in therapeutic applications. Special attention is given to targeted delivery mechanisms, surface modifications for improved biocompatibility, and recent advancements in cancer and gene therapies. Despite significant preclinical successes, clinical translation remains challenged by biological barriers, manufacturing complexity, and regulatory hurdles. Future directions suggest a paradigm shift toward smart, multifunctional nanomaterials designed for precision medicine. This review underscores the critical need for multidisciplinary collaboration to overcome existing challenges and to fully realize the clinical potential of nanotechnology in targeted drug delivery.

Keywords: Nanotechnology, Targeted Drug Delivery, Nanocarriers, Cancer Therapy, Gene Therapy, Surface Modification.

CITE AS: Mugo Moses H. (2025). Nanotechnology in Medicine: Targeted Drug Delivery Systems. Research Output Journal of Public Health and Medicine 5(2):31-37. https://doi.org/10.59298/ROJPHM/2025/523137