Metabolomics-Based Stratification of Cancer Subtypes and Treatment

Okafor, Azubuike Ikechukwu and Ogar, Boniface Oyigoja

Department of Medical Biochemistry, University of Cross River State, Calabar, Nigeria

Email: okafor.azubuike@gmail.com; phone number: +2348035723454

ABSTRACT

Metabolomics, the comprehensive study of small molecules within biological systems, has emerged as a pivotal approach in cancer research, offering deep insights into tumor biology. This paper explores the role of metabolomics in the stratification of cancer subtypes and its implications for personalized treatment. The paper explored the biological basis of metabolomics in cancer, focusing on how metabolic alterations reflect the underlying molecular characteristics of different tumor subtypes. Various techniques, such as nuclear magnetic resonance (NMR), liquid chromatography (LC), and mass spectrometry (MS), are examined for their effectiveness in identifying metabolic biomarkers specific to certain cancer subtypes, particularly breast and lung cancers. Case studies highlight the potential of metabolomics to guide precision medicine by identifying subtype-specific metabolic fingerprints, which could revolutionize cancer diagnosis, prognosis, and treatment strategies. The integration of metabolomics into clinical oncology holds promise for the development of more targeted and effective therapies, ultimately improving patient outcomes.

Keywords: Metabolomics, Cancer Subtypes, Precision Medicine, Biomarkers, Tumor Metabolism.

CITATION: Okafor, Azubuike Ikechukwu and Ogar, Boniface Oyigoja (2023). Metabolomics-Based Stratification of Cancer Subtypes and Treatment. Research Output Journal of Public Health and Medicine 2(1):5-8.