Genetic Markers and Their Role in Predicting the Development of Benign Prostatic Hyperplasia (BPH)

Odile Patrick Thalia

Faculty of Biological Sciences Kampala International University Uganda

ABSTRACT

Benign prostatic hyperplasia (BPH) is a prevalent condition in aging men, characterized by the non-cancerous enlargement of the prostate gland, leading to bothersome lower urinary tract symptoms (LUTS) such as urinary urgency, frequency, and incomplete bladder emptying. While environmental and hormonal factors like androgen activity and chronic inflammation are well-known contributors to BPH development, genetic predisposition is increasingly recognized as a critical factor. A growing body of research has identified several genetic markers that may influence an individual’s susceptibility to BPH. This review explores the current understanding of these genetic markers, focusing on key findings from genome-wide association studies (GWAS), single nucleotide polymorphisms (SNPs), and the role of epigenetic modifications such as DNA methylation and non-coding RNAs in the pathogenesis of BPH. Additionally, the review discusses the potential application of these genetic markers in the early prediction of BPH, which could facilitate more personalized and targeted approaches to treatment. Despite the advances in this field, challenges such as the clinical translation of genetic findings and the integration of genetic screening into routine practice remain. The future direction of BPH research will likely focus on refining predictive models and exploring novel therapeutic avenues based on genetic insights.

Keywords: Genetic markers, benign prostatic hyperplasia, aging men, prostate gland, urinary tract, hormonal factors

CITE AS: Odile Patrick Thalia (2024). Genetic Markers and Their Role in Predicting the Development of Benign Prostatic Hyperplasia (BPH). Research Output Journal of Biological and Applied Science 4(3):1-5. https://doi.org/10.59298/ROJBAS/2024/4315