Cellular Mechanisms Modulated by Steroids in Inflammatory Disease Management: Exploring NF-κB Inhibition and Cytokine Production Pathways

Rukundo Sande Kibuuka

Faculty of Science and Technology Kampala International University Uganda

ABSTRACT

Chronic inflammation plays a pivotal role in numerous inflammatory diseases, where dysregulated immune responses lead to tissue damage and dysfunction. Glucocorticoids, a class of steroids, are widely utilized for their potent anti-inflammatory and immunosuppressive properties, primarily mediated through the inhibition of nuclear factor kappa B (NF-κB) signaling and the regulation of cytokine production. This review elucidates the cellular mechanisms by which steroids modulate inflammation, focusing on NF-κB inhibition and the balance between pro-inflammatory and anti-inflammatory cytokines. By binding to the glucocorticoid receptor, glucocorticoids not only prevent NF-κB’s translocation to the nucleus but also upregulate inhibitors like IκB, thus sustaining their anti-inflammatory effects. Furthermore, glucocorticoids effectively inhibit the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 while promoting anti-inflammatory cytokines like IL-10, restoring homeostasis in the immune response. Despite their efficacy, long-term glucocorticoid use is associated with significant adverse effects, necessitating the development of novel therapies. This review explores ongoing research into selective glucocorticoid receptor modulators and NF-κB inhibitors, which aim to optimize therapeutic outcomes while minimizing side effects. Understanding these cellular pathways is crucial for advancing targeted treatments for chronic inflammatory diseases.

Keywords: Chronic Inflammation, Glucocorticoids, NF-κB Inhibition, Cytokine Production, Immune Response.

CITE AS: Rukundo Sande Kibuuka. (2025). Cellular Mechanisms Modulated by Steroids in Inflammatory Disease Management: Exploring NF-κB Inhibition and Cytokine Production Pathways. Research Output Journal of Biological and Applied Science 5(1):40-44. https://doi.org/10.59298/ROJBAS/2025/514044