Biological Engineering of Novel Antibiotics                           

Nkurunziza Nshimirimana Niyungeko

Faculty of Science and Technology Kampala International University Uganda

ABSTRACT

The emergence of antibiotic-resistant bacteria has created a significant public health crisis, necessitating the development of novel antibiotics. Traditional methods of antibiotic discovery have reached a plateau, prompting the exploration of biological engineering approaches to uncover new antibiotics. This paper reviews the historical significance of antibiotics, the mechanisms of antibiotic resistance, and the challenges in developing new antibiotics. It highlights synthetic biology as a promising approach, utilizing genetic enhancement and metabolic engineering to produce novel antibiotics. Case studies, such as the development of streptomycin, demonstrate the potential of biological engineering in addressing antibiotic resistance. The paper concludes by discussing future perspectives and the need for continued innovation in antibiotic discovery to combat the growing threat of multidrug-resistant bacteria.

Keywords: Antibiotic resistance, Biological engineering, Synthetic biology, Novel antibiotics, Metabolic engineering.

CITATION: Nkurunziza Nshimirimana Niyungeko. Biological Engineering of Novel Antibiotics. Research Output Journal of Engineering and Scientific Research. 2024 3(1):50-55.