Adaptogenic Herbs in Adrenal Insufficiency: A Review

Omeye Francis I.

Faculty of Medicine Kampala International University Uganda

ABSTRACT

Adrenal insufficiency is a condition marked by insufficient adrenal hormone production, leading to fatigue, hypotension, and metabolic imbalances. Conventional treatment mainly involves hormone replacement therapy, but increasing interest in complementary medicine has highlighted adaptogenic herbs as potential therapeutic options. Adaptogens such as Rhodiola rosea, Withania somnifera (Ashwagandha), Panax ginseng, and Eleutherococcus senticosus help modulate stress response systems, support adrenal function, and improve resilience to chronic stress. This review explores the pathophysiology of adrenal insufficiency, mechanisms of action of key adaptogenic herbs, and available clinical and preclinical evidence supporting their use. Additionally, it examines safety profiles, recommended dosages, and potential interactions with conventional treatments. While preliminary studies suggest adaptogens may enhance adrenal health and stress adaptation, more rigorous clinical trials are needed to confirm efficacy and establish standardized guidelines. Future research should focus on long-term safety, optimal dosages, and integration with traditional therapies to maximize therapeutic benefits.

Keywords: Adaptogens, adrenal insufficiency, Rhodiola rosea, Withania somnifera, Panax ginseng, Eleutherococcus senticosus, stress adaptation, adrenal fatigue

CITE AS: Omeye Francis I. (2025). Adaptogenic Herbs in Adrenal Insufficiency: A Review. Research Output Journal of Public Health and Medicine 5(3):7-11. https://doi.org/10.59298/ROJPHM/2025/53711