Customizing Cancer Treatments: Engineering Patient-Specific Therapies                                                         

Omutindo Nyakayo A.

Faculty of Science and Technology Kampala International University Uganda

ABSTRACT

The advancement of personalized cancer treatment marks a pivotal transformation in oncology, offering hope for more effective, patient-specific therapeutic strategies. Traditional cancer research, often reliant on animal models or generic cell lines, fails to address the vast heterogeneity present in human tumors. Recent breakthroughs in genomic sequencing, bioengineering, and nanomedicine have enabled the design of targeted treatments tailored to individual tumor profiles. By leveraging technologies such as tumor-on-chip models, microfluidic systems, pharmacogenomics, and immunotherapy innovations like CAR-T cells, clinicians are now better equipped to match therapies with patient-specific genetic, molecular, and microenvironmental contexts. The integration of artificial intelligence, digital twins, and advanced biomarkers further enhances patient selection and monitoring, optimizing therapeutic outcomes while minimizing off-target effects. Despite the promise, personalized cancer treatment faces challenges including high development costs, limited standardization, and regulatory complexities. Nonetheless, interdisciplinary collaborations and evolving clinical trial models are setting the stage for a new era in precision oncology, transforming cancer from a terminal illness into a manageable chronic condition.

Keywords: Personalized medicine, precision oncology, cancer genomics, CAR-T therapy, pharmacogenomics, tumor microenvironment, targeted therapy.

CITE AS: Omutindo Nyakayo A. (2025). Customizing Cancer Treatments: Engineering Patient-Specific Therapies. Research Output Journal of Public Health and Medicine 5(1):18-25. https://doi.org/10.59298/ROJPHM/2025/511825