The Impact of Microbiome on Human Health and Disease

Namukasa Mugerwa F.

Faculty of Medicine Kampala International University Uganda

ABSTRACT

An intricate and ever-changing assemblage of microbes inhabiting different regions of the human body, known as the human microbiome, is essential for preserving human health and exerting an impact on disease processes. This review examines the configuration, roles, and physiological interactions of the microbiome, especially in the gastrointestinal tract, and emphasises its substantial influence on the immune system, metabolic activities, and pathological conditions. Furthermore, we investigate the notion of dysbiosis, which is the association between changes in the makeup of the microbiome and diseases such as colorectal cancer, diabetes, and neurological problems. The review elaborates on existing approaches for investigating the microbiome, therapeutic treatments aimed at microbiota such as probiotics, prebiotics, and faecal microbiota transplantation, and their promise in the treatment of disorders linked to microbiome dysregulation. Elucidating the function of the microbiome in health and illness provides new perspectives on the preventive and treatment approaches for diseases.

Keywords: Human Microbiome, Gut Microbiota, Dysbiosis, Immune System, Microbiome and Disease.

CITATION: Namukasa Mugerwa F. The Impact of Microbiome on Human Health and Disease. Research Output Journal of Biological and Applied Science, 2024 3(3):19-22.